![]() ![]() ![]() From April–June 2019 to April–June 2020, overall benzodiazepine deaths increased 42.9% (from 1,004 to 1,435), prescription benzodiazepine deaths increased 21.8% (from 921 to 1,122), and illicit benzodiazepine deaths increased 519.6% (from 51 to 316). From 2019 to 2020, benzodiazepine overdose ED visits per 100,000 ED visits increased (23.7%), both with opioid involvement (34.4%) and without (21.0%). This data gap was addressed by analyzing annual and quarterly trends in suspected benzodiazepine-involved nonfatal overdoses ¶ treated in emergency departments (EDs) (benzodiazepine overdose ED visits) during January 2019–December 2020 (32 states and the District of Columbia ) and benzodiazepine-involved overdose deaths (benzodiazepine deaths), which include both illicit and prescription benzodiazepines, during January 2019–June 2020 (23 states) from CDC’s Overdose Data to Action (OD2A) program. Availability of recent multistate trend data on nonfatal benzodiazepine-involved overdoses and involvement of illicit benzodiazepines in overdoses is limited. Nonfatal and fatal drug overdoses increased overall from 2019 to 2020 ( 1).* Illicit benzodiazepines (e.g., etizolam, flualprazolam, and flubromazolam) † were increasingly detected among postmortem and clinical samples in 2020, often with opioids, § and might have contributed to overall increases in drug overdoses. Improving naloxone availability and enhancing treatment access for persons using benzodiazepines and opioids and calling emergency services for overdoses involving benzodiazepines and opioids, coupled with primary prevention of drug use and misuse, could reduce morbidity and mortality. What are the implications for public health practice? During January–June 2020, 92.7% of benzodiazepine-involved deaths also involved opioids, and 66.7% involved illicitly manufactured fentanyls. From April–June 2019 to April–June 2020, prescription and illicit benzodiazepine-involved overdose deaths increased 21.8% and 519.6%, respectively. ![]() Benzodiazepine-involved overdose deaths decreased during 2017–2019 however, since 2019, the illicit benzodiazepine supply increased.įrom 2019 to 2020, benzodiazepine overdose visits per 100,000 emergency department visits increased (23.7%), both with (34.4%) and without (21.0%) opioid co-involvement. ![]()
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